Kojic acid can be produced from a variety of substances by fermentation with aspergillus, a fungus. Pure kojic acid is mainly produced by glucose fermentation. Kojic acid is a small molecular component with a molecular weight of 142.22, which can be absorbed directly through the skin.
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“Melanin,” as it is known, is the core ingredient that causes skin darkening and spots. Inhibit the generation of melanin, can play the role of whitening freckle. In the melanin production process, “tyrosinase” is an essential catalyst. “Kojic acid” can use tyrosinase to grab copper ions, make tyrosinase lose activity, block the generation of melanin, to achieve the purpose of whitening freckle.
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For the safety of “kojic acid”, whether it will cause cancer in the end, scholars around the world have done a lot of research, interested partners can search for yourself, English information, description is very detailed. Zhen briefly introduced the final conclusion: Kojic acid is not an acute, chronic, or reproductive toxic substance, and although some animal data suggest tumor promotion and weak carcinogenesis, kojic acid is absorbed very slowly from human skin into the circulation and may not reach the threshold for these effects. Kojic acid is safe in cosmetics at concentrations below 2%.
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Studies have shown that the use of cream containing 1% lactic acid face smear, respectively at 0.5, 1, 1.5, 3, 6, 12, 24 h test users of blood kojic acid content, all plasma concentrations were only slightly above the normal value of 1 ng, no adverse reactions were observed. Kojic acid enters the bloodstream through the skin at very low levels and has little effect on the body. In rats, kojic acid has no reproductive toxicity and does not cause fetal aberration or produce reproductive toxins. And this experiment belongs to the feeding class, if through the skin smear, do not worry.
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In a patch trial of 220 female patients, there was no evidence that less than 2% of kojic acid products caused contact dermatitis. In terms of phototoxicity, kojic acid has not been shown to be phototoxic and does not cause delayed contact reactions. Therefore, products containing kojic acid can be used during the day.
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