Magnolol is a bisphenol compound and is the main active component of Magnolia officinalis. Magnolol was first isolated from Magnolia officinalis in 1930. Magnolol is a fine brown to white powder with an aromatic, pungent, slightly bitter smell. Monomer is colorless acicular crystal (water), melting point 102℃. Soluble in benzene, ether, chloroform, acetone and common organic solvents. It is insoluble in water, but readily dissolves in dilute caustic soda solutions, forming sodium salts. Magnolol has antibacterial, anti-inflammatory, antioxidant, anti-tumor and other effects, and can relieve muscle tension and relax muscles
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Magnolol was first recorded in Shennong Materia Medica and listed as a medium product. Magnoliaofficinalis extract is extracted from the dried root bark, stem bark or branch bark of Magnoliaofficinalis, etc. Commercial extracts are usually standardized for the content of magnolol and magnolol.
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Magnolol had obvious bacteriostasis effect, and had the lowest bacteriostasis concentration to Candida albicans, microspore, tinea microphylla, Aspergillus Niger, Cryptococcus neoforme, Candida albicans, Bacillus subtilis and Mycobacterium gray mold. Magnolol has the ability to kill bacteria in the mouth and eliminate bad breath. It has become one of the main ingredients in menthol and chewing gum.
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The anti-inflammatory effect of magnolol may be related to the inhibition of AA metabolic pathway and lysosomal release in cells. The formation of superoxide anion and P in rat neutrophils were determined by microplate method and fluorescence colorimetry. Glucosidase release and lysozyme release. The results showed that free radicals produced superoxide anions at concentrations of 1-1009m /L in neutropenia, and significantly inhibited the release of P glucosidase and lysozyme activated neutrophils when the concentration was greater than 109M/L. In addition, free radicals can attenuate sepsis caused by gastroenteritis.
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