NMN, which stands for nicotinamide mononucleotide, is found in many foods that people eat daily, such as fruits and vegetables. It is also inherent in the human body. In human body, NMN is the direct precursor of coenzyme I (NAD+), that is, NMN is the direct raw material of coenzyme 1. NMN can be converted to coenzyme I in one step.
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In short, coenzyme 1 (NAD+) is present in every cell and performs a variety of functions: providing energy for metabolism, building new cellular components, resisting free radicals, repairing DNA damage and transmitting signals. Studies have shown that coenzyme 1 (NAD+) is not only an important raw material of cellular DNA repair system, but also a key liaison factor responsible for energy synthesis between nucleus and mitochondria. Intermediates and linking factors, or more generally, intermediate materials and initiation signals. Many cellular responses lacking coenzyme 1 (NAD+) are stopped and attenuated, or they cannot continue. There are more than 5,000 cellular responses in the human body, more than half of which are related to coenzyme 1 (NAD+). Coenzyme 1 can be said to be the most important coenzyme in human body, such as glucose, fat, amino acid and alcohol metabolism, need the participation of coenzyme 1. The level of coenzyme 1 (NAD+) decreased with the increase of age. Coenzyme 1 (NAD+) levels drop by half every 20 years. A decrease in coenzyme 1 (NAD+) leads to a decrease in related cellular responses and metabolism, leading to some obvious changes such as wrinkles, hair loss, low energy, fatigue, etc. These are all problems of poor metabolism and cellular response.
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Functions
NMN can effectively and rapidly promote the synthesis of coenzyme 1 (NAD+) in various tissues and even brain tissues with good safety. After taking NMN, it can be completely absorbed through the digestive system, enter the blood within 2-3 minutes, improve the content of NMN in the tissue within 15 minutes, and rapidly improve the level of coenzyme 1 (NAD+) in the blood, liver, heart and other organs.
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Under certain experimental conditions, NAD+ precursors can prevent or even reverse neuronal damage and degeneration associated with hearing loss, retinal injury, traumatic brain injury (TBI) and peripheral neuropathy, showing strong and extensive neuronal protection.
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Sirtuins can respond to intracellular NAD+ levels, thus transforming and outputting the signal of “increased NAD+” into several biological activities involving cell damage repair and metabolic regulation. This characteristic endows NAD+ enhancers with great health care and therapeutic potential. Including biological clock regulation, neuroprotection, anti-aging of skeletal muscle, cardiovascular protection, improvement of metabolic disorders, liver and kidney function protection and so on.
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