Nicotinamide is an inhibitor of Sirtuin, and its inhibition does not imply premature senescence of cells. At least for now, there is no direct confirmation, and further research is needed. In contrast, resveratrol only activates Sirtuin, so skin care products and supplements with resveratrol are also currently popular. However, non-apoptosis can also lead to tumor, both of which have advantages and disadvantages. In addition, nicotinamide concentration was higher in laboratory nicotinamide induced cell premature senescence model. Nicotinamide, which has a fancy name, is actually vitamin B3, one of the 13 essential amino acids in the body. Both the FDA and CFDA currently allow nicotinamide to be added to skin care products.
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It says nicotinamide is one of the 13 essential vitamins and a nutrient for hair and nails. There are a number of patents that show that nicotinamide does cause hair growth, but it needs to be converted to niacin. Niacin is not the same as nicotinamide. Niacin is used in hypertension because of its peripheral vascular dilatation effect. Hyperlipidemia and other metabolic diseases, because niacin improves blood vessel supply function, conducive to hair growth.
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Nicotinamide really doesn’t hydrolyze as easily as we think to form niacin, which can cause side effects like redness and tingling. Adverse reactions occurred when using nicotinamide skin care products, mainly from the mixture of nicotinic acid in the skin care products of raw materials (even if good raw materials are difficult to avoid the mixture) and formula problems (ideal PH5-7). Individual people vary greatly in how their skin reacts to irritants, just like when you order takeout and choose food that is slightly spicy. For some people who can’t eat spicy food, it is extremely spicy, and they can’t eat a bite.
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Nicotinamide is for synthetic ingredients into the human body, its concentration does not act directly on the actual effect that protect skin, the skin of different concentrations of nicotinamide adaptability are limited and periodic, consumer is in use process should pay attention to contain nicotinamide to protect skin to taste the degree of stimulation to the skin, while the nicotinamide cost is not high, but not content, the higher the better.
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