Azelaic acid is an acid, and all acids can cause irritation and discomfort when applied to the skin. Compared with other acids, azelaic acid is mild and less irritating. Some users experience itching, burning, tingling and other symptoms, which are usually mild and short-lived. Always moisturize before use, and then apply azelaic acid. Daub dot shape in a place first, wait 10-15 minutes without obvious discomfort, can use large area. Azelaic acid has no photosensitivity and can also be used during the day, usually twice a day.
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In the 1970s, Dr. Marceua Nazzaro-Porro discovered the whitening effect of azelaic acid on skin while studying the white spots of tinea versicolor caused by pityrospora pityrospora. A lot of patients in the treatment of chloasma, acne imprint, gradually found that the original acne acne subside, pores become fine, the amount of skin oil is smaller, which makes another effect of azelaic acid – anti-inflammatory fat inhibition has become the focus of scholars.
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Studies have shown that in the treatment of pigmentation diseases, 20% azelaic acid and 4% hydroquinone (hydroquinone) ointment effect is comparable, significantly better than 2% hydroquinone ointment. Considering the cytotoxicity of hydroquinone cream, long-term use of high concentration is not recommended. 20% azelaic acid can be considered as a substitute for hydroquinone cream in clinical practice.
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Take a look at its whitening effect, and he can inhibit coning neuraminidase, reduce melanin cell number of dendrites and active, the most important thing is that this inhibition is highly selective, for a healthy cells (including health melanocytes) there is no reaction, only has an effect on the active melanin cell, speaking of which, we have learned, The whitening and freckling of azelaic acid, the process of brightening skin color, will not appear false white spots, excessive pigment loss this uneven phenomenon of pigment.
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Inhibit the transformation of testosterone to dihydrotestosterone, can effectively reduce sebum secretion to rescue oily face, and also has keratin regulation, anti-hair follicle tube keratosis, reduce the occurrence and development of acne from the root. Especially for acne, A foreign randomized single-blind multicentre clinical observation of 289 cases of acne treatment, 0.05% retinoic acid cream as the control group, the results showed that 20% azelelic acid in the treatment of acne, and 0.05% retinoic acid, erythema, scaly itching rate is significantly lower than that of retinoic acid.
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